Negative co-receptors on lymphocytes
RJ Greenwald, YE Latchman, AH Sharpe - Current opinion in immunology, 2002 - Elsevier
RJ Greenwald, YE Latchman, AH Sharpe
Current opinion in immunology, 2002•ElsevierThe past year has seen significant advances in our understanding of critical roles of
negative immunoregulatory signals delivered through the B7–CD28 superfamily in
regulating T cell activation and tolerance. Structural data on CTLA-4 have provided novel
insights into the inhibitory functions of CTLA-4. Initial characterization of the PD-1–PD-1-
ligand pathway has revealed that this pathway can downregulate TCR-and CD28-mediated
signals. Recent studies indicate that ICOS exerts distinct effects at different phases of an …
negative immunoregulatory signals delivered through the B7–CD28 superfamily in
regulating T cell activation and tolerance. Structural data on CTLA-4 have provided novel
insights into the inhibitory functions of CTLA-4. Initial characterization of the PD-1–PD-1-
ligand pathway has revealed that this pathway can downregulate TCR-and CD28-mediated
signals. Recent studies indicate that ICOS exerts distinct effects at different phases of an …
The past year has seen significant advances in our understanding of critical roles of negative immunoregulatory signals delivered through the B7–CD28 superfamily in regulating T cell activation and tolerance. Structural data on CTLA-4 have provided novel insights into the inhibitory functions of CTLA-4. Initial characterization of the PD-1–PD-1-ligand pathway has revealed that this pathway can downregulate TCR- and CD28-mediated signals. Recent studies indicate that ICOS exerts distinct effects at different phases of an immune response: ICOS can inhibit as well as stimulate T cell responses.
Elsevier
