Purpose: Locoregional tumor control for locally advanced cancers with radiation therapy has
been unsatisfactory. This is in part associated with the phenomenon of tumor hypoxia.
Assessing hypoxia in human tumors has been difficult due to the lack of clinically
noninvasive and reproducible methods. A recently developed positron emission tomography
(PET) imaging-based hypoxia measurement technique which employs a Cu (II)-diacetyl-bis
(N4-methylthiosemicarbazone)(Cu-ATSM) tracer is of great interest. Oxygen electrode …