Identification of a T cell chemotactic factor in the cerebrospinal fluid of HIV-1-infected individuals as interferon-γ inducible protein 10
SA Kolb, B Sporer, F Lahrtz, U Koedel… - Journal of …, 1999 - Elsevier
Central nervous system (CNS) involvement is a prominent feature of human
immunodeficiency virus (HIV-1) infection. Monocytes and CD4+ T cells traverse the blood
brain barrier (BBB), and serve as vehicles for the virus and perpetrators for brain pathology
by their production of neurotoxins. In the present study cerebrospinal fluid (CSF) samples
from HIV-1-infected patients were analyzed for the presence of chemotactic factors. All 36
CSF samples from the patients were positive for the CXC chemokine interferon-γ inducible …
immunodeficiency virus (HIV-1) infection. Monocytes and CD4+ T cells traverse the blood
brain barrier (BBB), and serve as vehicles for the virus and perpetrators for brain pathology
by their production of neurotoxins. In the present study cerebrospinal fluid (CSF) samples
from HIV-1-infected patients were analyzed for the presence of chemotactic factors. All 36
CSF samples from the patients were positive for the CXC chemokine interferon-γ inducible …
