[HTML][HTML] β3-adrenoceptor control the cystic fibrosis transmembrane conductance regulator through a cAMP/protein kinase A-independent pathway
V Leblais, S Demolombe, G Vallette, D Langin… - Journal of Biological …, 1999 - ASBMB
In human cardiac myocytes, we have previously identified a functional β 3-adrenoceptor in
which stimulation reduces action potential duration. Surprisingly, in cardiac biopsies
obtained from cystic fibrosis patients, β 3-adrenoceptor agonists produced no effects on
action potential duration. This result suggests the involvement of cystic fibrosis
transmembrane conductance regulator (CFTR) chloride current in the electrophysiological
effects of β 3-adrenoceptor stimulation in non-cystic fibrosis tissues. We therefore …
which stimulation reduces action potential duration. Surprisingly, in cardiac biopsies
obtained from cystic fibrosis patients, β 3-adrenoceptor agonists produced no effects on
action potential duration. This result suggests the involvement of cystic fibrosis
transmembrane conductance regulator (CFTR) chloride current in the electrophysiological
effects of β 3-adrenoceptor stimulation in non-cystic fibrosis tissues. We therefore …
