MHC class II-expressing hepatocytes function as antigen-presenting cells and activate specific CD4 T lymphocyutes
J Herkel, B Jagemann, C Wiegard, JFG Lazaro… - Hepatology, 2003 - Elsevier
The ability to activate CD4 T cells is restricted to antigen-presenting cells that express major
histocompatibility complex (MHC) class II molecules. Parenchymal cells normally do not
express MHC class II molecules; however, in clinical hepatitis, viral or autoimmune,
hepatocytes often exhibit aberrant MHC class II expression. It is not known whether MHC
class II-expressing hepatocytes can function as antigen-presenting cells, but it has been
suggested that aberrant MHC class II expression by parenchymal cells may cause …
histocompatibility complex (MHC) class II molecules. Parenchymal cells normally do not
express MHC class II molecules; however, in clinical hepatitis, viral or autoimmune,
hepatocytes often exhibit aberrant MHC class II expression. It is not known whether MHC
class II-expressing hepatocytes can function as antigen-presenting cells, but it has been
suggested that aberrant MHC class II expression by parenchymal cells may cause …
