Maternal Genistein Alters Coat Color and Protects Avy Mouse Offspring from Obesity by Modifying the Fetal Epigenome

DC Dolinoy, JR Weidman… - Environmental health …, 2006 - ehp.niehs.nih.gov
Genistein, the major phytoestrogen in soy, is linked to diminished female reproductive
performance and to cancer chemoprevention and decreased adipose deposition. Dietary
genistein may also play a role in the decreased incidence of cancer in Asians compared
with Westerners, as well as increased cancer incidence in Asians immigrating to the United
States. Here, we report that maternal dietary genistein supplementation of mice during
gestation, at levels comparable with humans consuming high-soy diets, shifted the coat …