Generation of T cell regulatory activity by plasmacytoid dendritic cells and tryptophan catabolism
P Puccetti, F Fallarino - Blood Cells, Molecules, and Diseases, 2008 - Elsevier
Plasmacytoid dendritic cells (pDCs) represent a specialized cell population that produces
large amounts of type I interferons. Recently, murine and human pDCs have been credited
with a unique ability to express the inducible, tolerogenic enzyme indoleamine 2, 3-
dioxygenase (IDO) as an effector means of regulatory T cell function and thus mediate
immunosuppression in specific settings. Here we review and further clarify specific features
of the relative efficacy and mechanisms of IDO induction in pDCs after 'ligand'engagement …
large amounts of type I interferons. Recently, murine and human pDCs have been credited
with a unique ability to express the inducible, tolerogenic enzyme indoleamine 2, 3-
dioxygenase (IDO) as an effector means of regulatory T cell function and thus mediate
immunosuppression in specific settings. Here we review and further clarify specific features
of the relative efficacy and mechanisms of IDO induction in pDCs after 'ligand'engagement …