Influence of dibutyryl cyclic AMP on thymidine uptake by herpes simplex virus infected cells and the intracellular level of cyclic AMP
K Bittlingmaier, D Schneider, D Falke - Biochimica et Biophysica Acta (BBA) …, 1977 - Elsevier
Dibutyryl cyclic AMP inhibits the increase of dThd and BrdUrd transport normally observed
after infection with Herpesvirus hominis, type I and II. Incorporation is also reduced.
Inhibition of uptake is non-competitive as analysed by the Lineweaver-Burk plot. Addition of
this drug to infected cells also reduces the activity of the thymidine kinase (EC 2.7. 1.75).
Transport of dUrd, dCyd and dAdo is not reduced. 4–8 h after infection with thymidine kinase
(+) herpes strains the level of cAMP increases. On infection with a thymidine kinase (−) virus …
after infection with Herpesvirus hominis, type I and II. Incorporation is also reduced.
Inhibition of uptake is non-competitive as analysed by the Lineweaver-Burk plot. Addition of
this drug to infected cells also reduces the activity of the thymidine kinase (EC 2.7. 1.75).
Transport of dUrd, dCyd and dAdo is not reduced. 4–8 h after infection with thymidine kinase
(+) herpes strains the level of cAMP increases. On infection with a thymidine kinase (−) virus …
