Neutrophils: molecules, functions and pathophysiological aspects
V Witko-Sarsat, P Rieu, B Descamps-Latscha… - Laboratory …, 2000 - nature.com
V Witko-Sarsat, P Rieu, B Descamps-Latscha, P Lesavre, L Halbwachs-Mecarelli
Laboratory investigation, 2000•nature.comCONCLUSION The notion that inflammation is the net resultant of pro and contra
inflammatory pathways (Fauve, 1980) is well illustrated by the dual role of neutrophils which
combine an anti-infectious and a proinflammatory role (Klebanoff, 1992; Ward, 1999; Weiss,
1989). The aim of this report is to review the main physiological and pathogenic activities of
neutrophils—ie, adherence and migration, degranulation and release of inflammatory
mediators, phagocytosis and apoptosis—in the light of the most recent molecular data on …
inflammatory pathways (Fauve, 1980) is well illustrated by the dual role of neutrophils which
combine an anti-infectious and a proinflammatory role (Klebanoff, 1992; Ward, 1999; Weiss,
1989). The aim of this report is to review the main physiological and pathogenic activities of
neutrophils—ie, adherence and migration, degranulation and release of inflammatory
mediators, phagocytosis and apoptosis—in the light of the most recent molecular data on …
CONCLUSION
The notion that inflammation is the net resultant of pro and contra inflammatory pathways (Fauve, 1980) is well illustrated by the dual role of neutrophils which combine an anti-infectious and a proinflammatory role (Klebanoff, 1992; Ward, 1999; Weiss, 1989). The aim of this report is to review the main physiological and pathogenic activities of neutrophils—ie, adherence and migration, degranulation and release of inflammatory mediators, phagocytosis and apoptosis—in the light of the most recent molecular data on extracellular effectors and regulators, membrane receptors, and intracellular signaling pathways involved in these functions.
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