Disease progression in Hutchinson-Gilford progeria syndrome: impact on growth and development
LB Gordon, KM McCarten, A Giobbie-Hurder… - …, 2007 - publications.aap.org
OBJECTIVES. Hutchinson-Gilford progeria syndrome is a rare and uniformly fatal segmental
“premature aging” disease that affects a variety of organ systems. We sought to more clearly
define the bone and weight abnormalities in patients with progeria as potential outcome
parameters for prospective clinical trials. PATIENTS AND METHODS. We collected and
analyzed longitudinal medical information, both retrospectively and prospectively, from a
total of 41 children with Hutchinson-Gilford progeria syndrome spanning 14 countries, from …
“premature aging” disease that affects a variety of organ systems. We sought to more clearly
define the bone and weight abnormalities in patients with progeria as potential outcome
parameters for prospective clinical trials. PATIENTS AND METHODS. We collected and
analyzed longitudinal medical information, both retrospectively and prospectively, from a
total of 41 children with Hutchinson-Gilford progeria syndrome spanning 14 countries, from …