More on: fluvastatin inhibits up‐regulation of tissue factor expression by antiphospholipid antibodies on endothelial cells
SS Pierangeli, DE Ferrara - Journal of Thrombosis and Haemostasis, 2005 - jthjournal.org
[2]. In that study, we demonstrated that fluvastatin reversed the expression of tissue factor
(TF) on endothelial cells (ECs) induced by antiphospholipid (aPL) antibodies. These effects
were dependent on the amount of antibody and concentration of the drug. Other studies
have also shown that fluvastatin reverses the prothrombotic and pro-inflammatory effects of
aPL antibodies both in vitro and in in vivo animal models. Meroni et al. showed that
fluvastatin prevented the expression of adhesion molecules and interleukin-6 in ECs treated …
(TF) on endothelial cells (ECs) induced by antiphospholipid (aPL) antibodies. These effects
were dependent on the amount of antibody and concentration of the drug. Other studies
have also shown that fluvastatin reverses the prothrombotic and pro-inflammatory effects of
aPL antibodies both in vitro and in in vivo animal models. Meroni et al. showed that
fluvastatin prevented the expression of adhesion molecules and interleukin-6 in ECs treated …
