[HTML][HTML] Maternal methyl supplements in mice affect epigenetic variation and DNA methylation of offspring
CA Cooney, AA Dave, GL Wolff - The Journal of nutrition, 2002 - Elsevier
This study was designed to determine if maternal dietary methyl supplements increase DNA
methylation and methylation-dependent epigenetic phenotypes in mammalian offspring.
Female mice of two strains were fed two levels of dietary methyl supplement or control diet
prior to and during pregnancy. Offspring of these mice vary in phenotype, which is
epigenetically determined and affects health and 2-y survival. Phenotype and DNA
methylation of a long terminal repeat (LTR) controlling expression of the agouti gene were …
methylation and methylation-dependent epigenetic phenotypes in mammalian offspring.
Female mice of two strains were fed two levels of dietary methyl supplement or control diet
prior to and during pregnancy. Offspring of these mice vary in phenotype, which is
epigenetically determined and affects health and 2-y survival. Phenotype and DNA
methylation of a long terminal repeat (LTR) controlling expression of the agouti gene were …
