[HTML][HTML] Protein C supports platelet binding and activation under flow: role of glycoprotein Ib and apolipoprotein E receptor 2
TC White, MA Berny, EI Tucker, RT Urbanus… - Journal of Thrombosis …, 2008 - Elsevier
Summary Background: Activated protein C (APC) regulates thrombin generation and inhibits
apoptosis. Endothelial protein C receptor (EPCR)-bound protein C is activated by
thrombomodulin-bound thrombin. APC inactivates coagulation factors (F) Va/VIIIa and
generates cytoprotective signaling downstream of protease-activated receptor-1 (PAR-1).
Binding of APC to EPCR both modifies and induces PAR-1 signaling, but it is unknown if
protein C interacts with cells in an alternative manner. Aim: To determine whether platelets …
apoptosis. Endothelial protein C receptor (EPCR)-bound protein C is activated by
thrombomodulin-bound thrombin. APC inactivates coagulation factors (F) Va/VIIIa and
generates cytoprotective signaling downstream of protease-activated receptor-1 (PAR-1).
Binding of APC to EPCR both modifies and induces PAR-1 signaling, but it is unknown if
protein C interacts with cells in an alternative manner. Aim: To determine whether platelets …