[HTML][HTML] Glypican-1 is a vehicle for polyamine uptake in mammalian cells: a pivotal role for nitrosothiol-derived nitric oxide
M Belting, K Mani, M Jönsson, F Cheng… - Journal of Biological …, 2003 - ASBMB
Polyamines (putrescine, spermidine, and spermine) are essential for growth and survival of
all cells. When polyamine biosynthesis is inhibited, there is up-regulation of import. The
mammalian polyamine transport system is unknown. We have previously shown that the
heparan sulfate (HS) side chains of recycling glypican-1 (Gpc-1) can sequester spermine,
that intracellular polyamine depletion increases the number of NO-sensitive N-unsubstituted
glucosamines in HS, and that NO-dependent cleavage of HS at these sites is required for …
all cells. When polyamine biosynthesis is inhibited, there is up-regulation of import. The
mammalian polyamine transport system is unknown. We have previously shown that the
heparan sulfate (HS) side chains of recycling glypican-1 (Gpc-1) can sequester spermine,
that intracellular polyamine depletion increases the number of NO-sensitive N-unsubstituted
glucosamines in HS, and that NO-dependent cleavage of HS at these sites is required for …
