[HTML][HTML] Phospholipid transfer protein deficiency impairs apolipoprotein-B secretion from hepatocytes by stimulating a proteolytic pathway through a relative deficiency …
XC Jiang, Z Li, R Liu, XP Yang, M Pan, L Lagrost… - Journal of Biological …, 2005 - ASBMB
Genetic deficiency of the plasma phospholipid transfer protein (PLTP) in mice unexpectedly
causes a substantial impairment in liver secretion of apolipoprotein-B (apoB), the major
protein of atherogenic lipoproteins. To explore the mechanism, we examined the three
known pathways for hepatic apoB secretory control, namely endoplasmic reticulum
(ER)/proteasome-associated degradation (ERAD), post-ER pre-secretory proteolysis
(PERPP), and receptor-mediated degradation, also known as re-uptake. First, we found that …
causes a substantial impairment in liver secretion of apolipoprotein-B (apoB), the major
protein of atherogenic lipoproteins. To explore the mechanism, we examined the three
known pathways for hepatic apoB secretory control, namely endoplasmic reticulum
(ER)/proteasome-associated degradation (ERAD), post-ER pre-secretory proteolysis
(PERPP), and receptor-mediated degradation, also known as re-uptake. First, we found that …
