[CITATION][C] TNF as an activator of vascular endothelium
JS Pober - Annales de l'Institut Pasteur/Immunologie, 1988 - Elsevier
Tumour necrosis factor frNF), a protein secreted by macroph. ages in response to
inflammatory or~ mmune processes, is an endogenous pleiotropic inflammatory mediator.
TNF has highaffinity surface receptors on almost every cell type tested and shares these
receptors with the structur~ ly reiated cytokine lymphotoxin (LT), an activated T-cell product
[I]. Remarkably, there is also extensive overlap of bie'ogical activity of TNF (and LT) with
interleukin-I (IL-1), a family of at least two polypeptides structurally unrelated to TNF or LT …
inflammatory or~ mmune processes, is an endogenous pleiotropic inflammatory mediator.
TNF has highaffinity surface receptors on almost every cell type tested and shares these
receptors with the structur~ ly reiated cytokine lymphotoxin (LT), an activated T-cell product
[I]. Remarkably, there is also extensive overlap of bie'ogical activity of TNF (and LT) with
interleukin-I (IL-1), a family of at least two polypeptides structurally unrelated to TNF or LT …
