Urokinase receptor deficiency accelerates renal fibrosis in obstructive nephropathy
G Zhang, H Kim, X Cai, JM López-Guisa… - Journal of the …, 2003 - journals.lww.com
The urokinase cellular receptor (uPAR) recognizes the N-terminal growth factor domain of
urokinase-type plasminogen activator (uPA) and is expressed by several cell types. The
present study was designed to test the hypothesis that uPAR regulates the renal fibrogenic
response to chronic injury. Groups of uPAR wild-type (+/+) and deficient (−/−) mice were
investigated between 3 and 14 d after unilateral ureteral obstruction (UUO) or sham surgery.
Not detected in normal kidneys, uPAR mRNA was expressed in response to UUO in the+/+ …
urokinase-type plasminogen activator (uPA) and is expressed by several cell types. The
present study was designed to test the hypothesis that uPAR regulates the renal fibrogenic
response to chronic injury. Groups of uPAR wild-type (+/+) and deficient (−/−) mice were
investigated between 3 and 14 d after unilateral ureteral obstruction (UUO) or sham surgery.
Not detected in normal kidneys, uPAR mRNA was expressed in response to UUO in the+/+ …
