Overview of hepatitis C virus genome structure, polyprotein processing, and protein properties
KE Reed, CM Rice - The Hepatitis C Viruses, 2000 - Springer
KE Reed, CM Rice
The Hepatitis C Viruses, 2000•SpringerHepatitis C was first recognized as a distinct form of liver disease in the mid-1970s with the
advent of diagnostic tests for hepatitis A and B virus infection (A LTER et al. 1975; P RINCE
et al. 1974). The etiologic agent of hepatitis C was proposed to be a small, enveloped virus
based on demonstrations of its transmissibility to chimpanzees (A LTER et al. 1978; H
OLLINGER et al. 1978; T ABOR et al. 1978), small size (< 80nm)(B RADLEY et al. 1985; HE
et al. 1987), and sensitivity to chloroform (B RADLEY et al. 1983; F EINSTONE et al. 1983) …
advent of diagnostic tests for hepatitis A and B virus infection (A LTER et al. 1975; P RINCE
et al. 1974). The etiologic agent of hepatitis C was proposed to be a small, enveloped virus
based on demonstrations of its transmissibility to chimpanzees (A LTER et al. 1978; H
OLLINGER et al. 1978; T ABOR et al. 1978), small size (< 80nm)(B RADLEY et al. 1985; HE
et al. 1987), and sensitivity to chloroform (B RADLEY et al. 1983; F EINSTONE et al. 1983) …
Abstract
Hepatitis C was first recognized as a distinct form of liver disease in the mid-1970s with the advent of diagnostic tests for hepatitis A and B virus infection (ALTER et al. 1975; PRINCE et al. 1974). The etiologic agent of hepatitis C was proposed to be a small, enveloped virus based on demonstrations of its transmissibility to chimpanzees (ALTER et al. 1978; HOLLINGER et al. 1978; TABOR et al. 1978), small size (< 80nm) (BRADLEY et al. 1985; HE et al. 1987), and sensitivity to chloroform (BRADLEY et al. 1983; FEINSTONE et al. 1983). The genome of hepatitis C virus (HCV) was first cloned in 1989 by screening a λgt11 cDNA expression library, derived from the plasma of a persistently infected chimpanzee, with hepatitis C patient serum (CHOO et al. 1989). Hybridization and nuclease digestion experiments indicated that the HCV genome consists of a single-stranded, positive-sense, RNA molecule (CHOO et al. 1989).
Springer
