A new type of transforming growth factor‐beta, TGF‐beta 3.
R Derynck, PB Lindquist, A Lee, D Wen, J Tamm… - The EMBO …, 1988 - embopress.org
R Derynck, PB Lindquist, A Lee, D Wen, J Tamm, JL Graycar, L Rhee, AJ Mason, DA Miller…
The EMBO journal, 1988•embopress.orgA new type of TGF‐beta, TGF‐beta 3, has been identified by cDNA characterization. The
amino acid sequence of mature TGF‐beta 3 and its precursor has been derived from porcine
and human cDNA sequences. The human TGF‐beta 3 gene is spread over seven exons as
in the case of the TGF‐beta 1 gene. Comparison with TGF‐beta 1 and‐beta 2 indicates a
strong conservation of the mature sequences, but a relaxed homology in the precursor
segments. TGF‐beta 3 mRNA is mainly expressed in cell lines from mesenchymal origin …
amino acid sequence of mature TGF‐beta 3 and its precursor has been derived from porcine
and human cDNA sequences. The human TGF‐beta 3 gene is spread over seven exons as
in the case of the TGF‐beta 1 gene. Comparison with TGF‐beta 1 and‐beta 2 indicates a
strong conservation of the mature sequences, but a relaxed homology in the precursor
segments. TGF‐beta 3 mRNA is mainly expressed in cell lines from mesenchymal origin …
A new type of TGF‐beta, TGF‐beta 3, has been identified by cDNA characterization. The amino acid sequence of mature TGF‐beta 3 and its precursor has been derived from porcine and human cDNA sequences. The human TGF‐beta 3 gene is spread over seven exons as in the case of the TGF‐beta 1 gene. Comparison with TGF‐beta 1 and ‐beta 2 indicates a strong conservation of the mature sequences, but a relaxed homology in the precursor segments. TGF‐beta 3 mRNA is mainly expressed in cell lines from mesenchymal origin, suggesting a biological role different from the other TGFs‐beta.
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