[HTML][HTML] Cancer genomes evolve by pulverizing single chromosomes
M Meyerson, D Pellman - Cell, 2011 - cell.com
Cell, 2011•cell.com
A report in this issue describes" chromothripsis," a new mechanism for genetic instability in
cancer cells. Chromothripsis appears to be a cataclysmic event in which a single
chromosome is fragmented and then reassembled. The phenomenon raises important
questions of how chromosome rearrangements can be confined to defined genome
segments.
cancer cells. Chromothripsis appears to be a cataclysmic event in which a single
chromosome is fragmented and then reassembled. The phenomenon raises important
questions of how chromosome rearrangements can be confined to defined genome
segments.
A report in this issue describes "chromothripsis," a new mechanism for genetic instability in cancer cells. Chromothripsis appears to be a cataclysmic event in which a single chromosome is fragmented and then reassembled. The phenomenon raises important questions of how chromosome rearrangements can be confined to defined genome segments.
cell.com