NF-Y and Sp1 cooperate for the transcriptional activation and cAMP response of human tissue inhibitor of metalloproteinases-2
ZD Zhong, K Hammani, WS Bae… - Journal of Biological …, 2000 - ASBMB
The balance between matrix metalloproteinases (MMPs) and tissue inhibitors of MMPs
(TIMPs) is a key determinant in the homeostasis of the extracellular matrix. We have
identified two cis-acting elements involved in the transcriptional regulation of TIMP-2. The
first is an inverted CCAAT box located at position− 73 to− 69 in the TIMP-2 promoter that
binds the transcription factor NF-Y. The second is a GAGGAGGGGG motif located at
position− 107 to− 98, that binds the transcription factors Sp1 and Sp3. NF-Y and Sp1 …
(TIMPs) is a key determinant in the homeostasis of the extracellular matrix. We have
identified two cis-acting elements involved in the transcriptional regulation of TIMP-2. The
first is an inverted CCAAT box located at position− 73 to− 69 in the TIMP-2 promoter that
binds the transcription factor NF-Y. The second is a GAGGAGGGGG motif located at
position− 107 to− 98, that binds the transcription factors Sp1 and Sp3. NF-Y and Sp1 …