[HTML][HTML] Androgen receptor regulation of the versican gene through an androgen response element in the proximal promoter
JT Read, M Rahmani, S Boroomand… - Journal of biological …, 2007 - ASBMB
Versican, one of the key components of prostatic stroma, plays a central role in tumor
initiation and progression. Here, we investigated promoter elements and mechanisms of
androgen receptor (AR)-mediated regulation of the versican gene in prostate cancer cells.
Using transient transfection assays in prostate cancer LNCaP and cervical cancer HeLa
cells engineered to express the AR, we demonstrate that the synthetic androgen R1881 and
dihydrotestosterone stimulate expression of a versican promoter-driven luciferase reporter …
initiation and progression. Here, we investigated promoter elements and mechanisms of
androgen receptor (AR)-mediated regulation of the versican gene in prostate cancer cells.
Using transient transfection assays in prostate cancer LNCaP and cervical cancer HeLa
cells engineered to express the AR, we demonstrate that the synthetic androgen R1881 and
dihydrotestosterone stimulate expression of a versican promoter-driven luciferase reporter …