[HTML][HTML] Rationally evolving MCP-1/CCL2 into a decoy protein with potent anti-inflammatory activity in vivo
AM Piccinini, K Knebl, A Rek, G Wildner… - Journal of biological …, 2010 - ASBMB
Leukocyte recruitment from the blood into injured tissues during inflammatory diseases is
the result of sequential events involving chemokines binding to their GPC receptors as well
as to their glycosaminoglycan (GAG) co-receptors. The induction and the crucial role of MCP-
1/CCL2 in the course of diseases that feature monocyte-rich infiltrates have been validated
in many animal models, and several MCP-1/CCL2 as well as CCR2 antagonists have since
been generated. However, despite some of them being shown to be efficacious in a number …
the result of sequential events involving chemokines binding to their GPC receptors as well
as to their glycosaminoglycan (GAG) co-receptors. The induction and the crucial role of MCP-
1/CCL2 in the course of diseases that feature monocyte-rich infiltrates have been validated
in many animal models, and several MCP-1/CCL2 as well as CCR2 antagonists have since
been generated. However, despite some of them being shown to be efficacious in a number …