[HTML][HTML] Memory of extracellular adenosine A2A purinergic receptor-mediated signaling in murine T cells
M Koshiba, H Kojima, S Huang, S Apasov… - Journal of Biological …, 1997 - ASBMB
Accumulation of extracellular and intracellular adenosine (Ado) under hypoxic conditions or
in the absence of adenosine deaminase results in lymphocyte depletion and in severe
combined immunodeficiency, which are currently explained by direct intracellular
lymphotoxicity of Ado metabolites. In support of the alternative," signaling" mechanism, we
show that extracellular Ado (extAdo) suppresses all tested T cell receptor (TCR)-triggered
effector functions of T lymphocytes including the TCR-triggered FasL mRNA up-regulation in …
in the absence of adenosine deaminase results in lymphocyte depletion and in severe
combined immunodeficiency, which are currently explained by direct intracellular
lymphotoxicity of Ado metabolites. In support of the alternative," signaling" mechanism, we
show that extracellular Ado (extAdo) suppresses all tested T cell receptor (TCR)-triggered
effector functions of T lymphocytes including the TCR-triggered FasL mRNA up-regulation in …
