[HTML][HTML] Deletion of Scap in alveolar type II cells influences lung lipid homeostasis and identifies a compensatory role for pulmonary lipofibroblasts
V Besnard, SE Wert, MT Stahlman, AD Postle… - Journal of biological …, 2009 - ASBMB
Pulmonary function after birth is dependent upon surfactant lipids that reduce surface
tension in the alveoli. The sterol-responsive element-binding proteins (SREBPs) are
transcription factors regulating expression of genes controlling lipid homeostasis in many
tissues. To identify the role of SREBPs in the lung, we conditionally deleted the SREBP
cleavage-activating protein gene, Scap, in respiratory epithelial cells (Scap Δ/Δ) in vivo.
Prior to birth (E18. 5), deletion of Scap decreased the expression of both SREBPs and a …
tension in the alveoli. The sterol-responsive element-binding proteins (SREBPs) are
transcription factors regulating expression of genes controlling lipid homeostasis in many
tissues. To identify the role of SREBPs in the lung, we conditionally deleted the SREBP
cleavage-activating protein gene, Scap, in respiratory epithelial cells (Scap Δ/Δ) in vivo.
Prior to birth (E18. 5), deletion of Scap decreased the expression of both SREBPs and a …