T follicular helper (T FH) cells have been shown to be critically required for the germinal
center (GC) reaction where B cells undergo class switch recombination and clonal selection
to generate high affinity neutralizing antibodies. However, detailed knowledge of the
physiological cues within the GC microenvironment that regulate T cell help is limited. The
cAMP-elevating, G s protein-coupled A2a adenosine receptor (A2aR) is an evolutionarily
conserved receptor that limits and redirects cellular immunity. However, the role of A2aR in …