Expression of IL-36 family cytokines and IL-37 but not IL-38 is altered in psoriatic skin
Plaque psoriasis is a common chronic inflammatory skin disease. To date, most efficient
antipsoriatic drugs are biologicals that inhibit some key cytokines in the pathogenetic
network of psoriasis. Interleukin (IL) 36a (gene symbol IL36A), IL-36b (IL36B), IL-36g
(IL36G), IL-36Ra (IL36RN), IL-37 (IL37) and IL-38 (IL1F10) are new members of the IL-1
cytokine family. We have recently conducted RNA sequencing of psoriatic lesional,
nonlesional and control skin [1]. Our whole transcriptome analysis revealed that most of …
antipsoriatic drugs are biologicals that inhibit some key cytokines in the pathogenetic
network of psoriasis. Interleukin (IL) 36a (gene symbol IL36A), IL-36b (IL36B), IL-36g
(IL36G), IL-36Ra (IL36RN), IL-37 (IL37) and IL-38 (IL1F10) are new members of the IL-1
cytokine family. We have recently conducted RNA sequencing of psoriatic lesional,
nonlesional and control skin [1]. Our whole transcriptome analysis revealed that most of …