Hypoxia signaling pathway in stem cell regulation: good and evil
Current stem cell reports, 2018•Springer
Abstract Purpose of Review This review summarizes the role of hypoxia and hypoxia-
inducible factors (HIFs) in the regulation of stem cell biology, specifically focusing on
maintenance, differentiation, and stress responses in the context of several stem cell
systems. Stem cells for different lineages/tissues reside in distinct niches, and are exposed
to diverse oxygen concentrations. Recent studies have revealed the importance of the
hypoxia signaling pathway for stem cell functions. Recent Findings Hypoxia and HIFs …
inducible factors (HIFs) in the regulation of stem cell biology, specifically focusing on
maintenance, differentiation, and stress responses in the context of several stem cell
systems. Stem cells for different lineages/tissues reside in distinct niches, and are exposed
to diverse oxygen concentrations. Recent studies have revealed the importance of the
hypoxia signaling pathway for stem cell functions. Recent Findings Hypoxia and HIFs …
Purpose of Review
This review summarizes the role of hypoxia and hypoxia-inducible factors (HIFs) in the regulation of stem cell biology, specifically focusing on maintenance, differentiation, and stress responses in the context of several stem cell systems. Stem cells for different lineages/tissues reside in distinct niches, and are exposed to diverse oxygen concentrations. Recent studies have revealed the importance of the hypoxia signaling pathway for stem cell functions.
Recent Findings
Hypoxia and HIFs contribute to maintenance of embryonic stem cells, generation of induced pluripotent stem cells, functionality of hematopoietic stem cells, and survival of leukemia stem cells. Harvest and collection of mouse bone marrow and human cord blood cells in ambient air results in fewer hematopoietic stem cells recovered due to the phenomenon of Extra PHysiologic Oxygen Shock/Stress (EPHOSS).
Summary
Oxygen is an important factor in the stem cell microenvironment. Hypoxia signaling and HIFs play important roles in modeling cellular metabolism in both stem cells and niches to regulate stem cell biology, and represent an additional dimension that allows stem cells to maintain an undifferentiated status and multilineage differentiation potential.
Springer