Importance β-Amyloid (Aβ) deposition and vascular brain injury (VBI) frequently co-occur
and are both associated with cognitive decline in aging. Determining whether a direct
relationship exists between them has been challenging. We sought to understand VBI's
influence on cognition and clinical impairment, separate from and in conjunction with
pathologic changes associated with Alzheimer disease (AD). Objective To examine the
relationship between neuroimaging measures of VBI and brain Aβ deposition and their …