[HTML][HTML] Reduced neutralisation of SARS-CoV-2 omicron B. 1.1. 529 variant by post-immunisation serum
W Dejnirattisai, RH Shaw, P Supasa, C Liu… - Lancet (London …, 2022 - ncbi.nlm.nih.gov
W Dejnirattisai, RH Shaw, P Supasa, C Liu, ASV Stuart, AJ Pollard, X Liu, T Lambe, D Crook…
Lancet (London, England), 2022•ncbi.nlm.nih.govAccording to WHO, SARS-CoV-2 is estimated to have caused 265 million infections and
more than 5 million deaths over the past 2 years. Current vaccines are based on the original
SARS-CoV-2 strain and are designed primarily to raise an antibody response against the
spike protein (S), although elicited T-cell responses can also contribute to protection from
severe disease. The SARS-CoV-2 RNA polymerase is intrinsically error prone, which results
in mutation to the viral genome. In the past year, several variants containing multiple …
more than 5 million deaths over the past 2 years. Current vaccines are based on the original
SARS-CoV-2 strain and are designed primarily to raise an antibody response against the
spike protein (S), although elicited T-cell responses can also contribute to protection from
severe disease. The SARS-CoV-2 RNA polymerase is intrinsically error prone, which results
in mutation to the viral genome. In the past year, several variants containing multiple …
According to WHO, SARS-CoV-2 is estimated to have caused 265 million infections and more than 5 million deaths over the past 2 years. Current vaccines are based on the original SARS-CoV-2 strain and are designed primarily to raise an antibody response against the spike protein (S), although elicited T-cell responses can also contribute to protection from severe disease.
The SARS-CoV-2 RNA polymerase is intrinsically error prone, which results in mutation to the viral genome. In the past year, several variants containing multiple mutations in S have been reported: alpha (B. 1.1. 7), beta (B. 1.351), gamma (P. 1), and delta (B. 1.617. 2). These variants contain mutations in the receptor binding motif, a small 25 amino acid patch at the tip of S that mediates interaction with the ACE2 receptor (one mutation in alpha, three in beta and gamma, and two in delta).
ncbi.nlm.nih.gov
