[HTML][HTML] Cerebral metabolic differences associated with cognitive impairment in Parkinson's disease
Y Tang, J Ge, F Liu, P Wu, S Guo, Z Liu, Y Wang… - PLoS …, 2016 - journals.plos.org
Y Tang, J Ge, F Liu, P Wu, S Guo, Z Liu, Y Wang, Y Wang, Z Ding, J Wu, C Zuo, J Wang
PLoS One, 2016•journals.plos.orgPurpose To characterize cerebral glucose metabolism associated with different cognitive
states in Parkinson's disease (PD) using 18F-fluorodeoxyglucose (FDG) and Positron
Emission Tomography (PET). Methods Three groups of patients were recruited in this study
including PD patients with dementia (PDD; n= 10), with mild cognitive impairment (PD-MCI;
n= 20), and with no cognitive impairment (PD-NC; n= 30). The groups were matched for age,
sex, education, disease duration, motor disability, levodopa equivalent dose and Geriatric …
states in Parkinson's disease (PD) using 18F-fluorodeoxyglucose (FDG) and Positron
Emission Tomography (PET). Methods Three groups of patients were recruited in this study
including PD patients with dementia (PDD; n= 10), with mild cognitive impairment (PD-MCI;
n= 20), and with no cognitive impairment (PD-NC; n= 30). The groups were matched for age,
sex, education, disease duration, motor disability, levodopa equivalent dose and Geriatric …
Purpose
To characterize cerebral glucose metabolism associated with different cognitive states in Parkinson’s disease (PD) using 18F-fluorodeoxyglucose (FDG) and Positron Emission Tomography (PET).
Methods
Three groups of patients were recruited in this study including PD patients with dementia (PDD; n = 10), with mild cognitive impairment (PD-MCI; n = 20), and with no cognitive impairment (PD-NC; n = 30). The groups were matched for age, sex, education, disease duration, motor disability, levodopa equivalent dose and Geriatric Depression Rating Scale (GDS) score. All subjects underwent a FDG-PET study. Maps of regional metabolism in the three groups were compared using statistical parametric mapping (SPM5).
Results
PD-MCI patients exhibited limited areas of hypometabolism in the frontal, temporal and parahippocampal gyrus compared with the PD-NC patients (p < 0.01). PDD patients had bilateral areas of hypometabolism in the frontal and posterior parietal-occipital lobes compared with PD-MCI patients (p < 0.01), and exhibited greater metabolic reductions in comparison with PD-NC patients (p < 0.01).
Conclusions
Compared with PD-NC patients, hypometabolism was much higher in the PDD patients than in PD-MCI patients, mainly in the posterior cortical areas. The result might suggest an association between posterior cortical hypometabolism and more severe cognitive impairment. PD-MCI might be important for early targeted therapeutic intervention and disease modification.
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