Background The hippocampus (HP) is part of the default mode network (DMN), and both are
key targets of Alzheimer's disease (AD). Because of widespread network degeneration, it
has been suggested that increasing HP disconnection from the DMN may lead to
progressive disinhibition of intra-HP synchronized activity. Methods To analyze HP local (ie,
within HP) and global (ie, within DMN) intrinsic functional connectivity (local/global intrinsic
functional connectivity [iFC]), healthy controls and patients with mild cognitive impairment …