Background Mast cells are significantly involved in IgE-mediated allergic reactions;
however, their roles in health and disease are incompletely understood. Objective We aimed
to define the proteome contained in mast cell releasates on activation to better understand
the factors secreted by mast cells that are relevant to the contribution of mast cells in
diseases. Methods Bone marrow–derived cultured mast cells (BMCMCs) and peritoneal cell–
derived mast cells were used as “surrogates” for mucosal and connective tissue mast cells …