[HTML][HTML] Muscle-specific TGR5 overexpression improves glucose clearance in glucose-intolerant mice
T Sasaki, Y Watanabe, A Kuboyama, A Oikawa… - Journal of Biological …, 2021 - ASBMB
TGR5, a G protein–coupled bile acid receptor, is expressed in various tissues and regulates
several physiological processes. In the skeletal muscle, TGR5 activation is known to induce
muscle hypertrophy; however, the effects on glucose and lipid metabolism are not well
understood, despite the fact that the skeletal muscle plays a major role in energy
metabolism. Here, we demonstrate that skeletal muscle–specific TGR5 transgenic (Tg) mice
exhibit increased glucose utilization, without altering the expression of major genes related …
several physiological processes. In the skeletal muscle, TGR5 activation is known to induce
muscle hypertrophy; however, the effects on glucose and lipid metabolism are not well
understood, despite the fact that the skeletal muscle plays a major role in energy
metabolism. Here, we demonstrate that skeletal muscle–specific TGR5 transgenic (Tg) mice
exhibit increased glucose utilization, without altering the expression of major genes related …
