Soluble CD14 is a nonspecific marker of monocyte activation
CL Shive, W Jiang, DD Anthony, MM Lederman - Aids, 2015 - journals.lww.com
CL Shive, W Jiang, DD Anthony, MM Lederman
Aids, 2015•journals.lww.comSoluble CD14 is associated with morbidity and mortality in HIV disease. It is a co-receptor for
lipopolysaccharide (LPS) that is released from monocytes upon activation. We demonstrate
here, that inflammatory cytokines can induce the release of sCD14 in peripheral blood
mononuclear cell cultures from healthy donors, and that TLR ligands other than LPS can
cause a decrease in the monocyte cell surface expression of CD14. Thus, sCD14 is a
marker of monocyte activation, not restricted to activation by LPS.
lipopolysaccharide (LPS) that is released from monocytes upon activation. We demonstrate
here, that inflammatory cytokines can induce the release of sCD14 in peripheral blood
mononuclear cell cultures from healthy donors, and that TLR ligands other than LPS can
cause a decrease in the monocyte cell surface expression of CD14. Thus, sCD14 is a
marker of monocyte activation, not restricted to activation by LPS.
Abstract
Soluble CD14 is associated with morbidity and mortality in HIV disease. It is a co-receptor for lipopolysaccharide (LPS) that is released from monocytes upon activation. We demonstrate here, that inflammatory cytokines can induce the release of sCD14 in peripheral blood mononuclear cell cultures from healthy donors, and that TLR ligands other than LPS can cause a decrease in the monocyte cell surface expression of CD14. Thus, sCD14 is a marker of monocyte activation, not restricted to activation by LPS.
Lippincott Williams & Wilkins