[PDF][PDF] Trimethoprim and sulfonamide resistance
P Huovinen, L Sundström, G Swedberg… - Antimicrobial agents …, 1995 - Am Soc Microbiol
P Huovinen, L Sundström, G Swedberg, O Sköld
Antimicrobial agents and chemotherapy, 1995•Am Soc MicrobiolTrimethoprim (TMP) and sulfonamides (SULs) are synthetic antibacterial agents. The first
SUL compounds were used in 1932, whereas TMP is a relatively new compound first used
in 1962 in England (69). Since 1968, TMP has been used in combination with SULs
because the combination of TMP-SULs was supposed to be synergistic in vitro (18).
However, clinical experience suggests that TMP-SUL combinations have no clear synergism
in vivo (2, 16, 112). In the 1970s, TMP alone came into use, first for the prophylaxis of urinary …
SUL compounds were used in 1932, whereas TMP is a relatively new compound first used
in 1962 in England (69). Since 1968, TMP has been used in combination with SULs
because the combination of TMP-SULs was supposed to be synergistic in vitro (18).
However, clinical experience suggests that TMP-SUL combinations have no clear synergism
in vivo (2, 16, 112). In the 1970s, TMP alone came into use, first for the prophylaxis of urinary …
Trimethoprim (TMP) and sulfonamides (SULs) are synthetic antibacterial agents. The first SUL compounds were used in 1932, whereas TMP is a relatively new compound first used in 1962 in England (69). Since 1968, TMP has been used in combination with SULs because the combination of TMP-SULs was supposed to be synergistic in vitro (18). However, clinical experience suggests that TMP-SUL combinations have no clear synergism in vivo (2, 16, 112). In the 1970s, TMP alone came into use, first for the prophylaxis of urinary tract infections and later for the treatment of acute urinary tract infections as well (81).
American Society for Microbiology