Specific imaging of bacterial infection using 6 ″-18F-fluoromaltotriose: a second-generation PET tracer targeting the maltodextrin transporter in bacteria
G Gowrishankar, J Hardy, M Wardak… - Journal of Nuclear …, 2017 - Soc Nuclear Med
Journal of Nuclear Medicine, 2017•Soc Nuclear Med
6 ″-18F-fluoromaltotriose is a PET tracer that can potentially be used to image and localize
most bacterial infections, much like 18F-FDG has been used to image and localize most
cancers. However, unlike 18F-FDG, 6 ″-18F-fluoromaltotriose is not taken up by
inflammatory lesions and appears to be specific to bacterial infections by targeting the
maltodextrin transporter that is expressed in gram-positive and gram-negative strains of
bacteria. Methods: 6 ″-18F-fluoromaltotriose was synthesized with high radiochemical …
most bacterial infections, much like 18F-FDG has been used to image and localize most
cancers. However, unlike 18F-FDG, 6 ″-18F-fluoromaltotriose is not taken up by
inflammatory lesions and appears to be specific to bacterial infections by targeting the
maltodextrin transporter that is expressed in gram-positive and gram-negative strains of
bacteria. Methods: 6 ″-18F-fluoromaltotriose was synthesized with high radiochemical …
6″-18F-fluoromaltotriose is a PET tracer that can potentially be used to image and localize most bacterial infections, much like 18F-FDG has been used to image and localize most cancers. However, unlike 18F-FDG, 6″-18F-fluoromaltotriose is not taken up by inflammatory lesions and appears to be specific to bacterial infections by targeting the maltodextrin transporter that is expressed in gram-positive and gram-negative strains of bacteria.
Methods
6″-18F-fluoromaltotriose was synthesized with high radiochemical purity and evaluated in several clinically relevant bacterial strains in cultures and in living mice. Results
6″-18F-fluoromaltotriose was taken up in both gram-positive and gram-negative bacterial strains. 6″-18F-fluoromaltotriose was also able to detect Pseudomonas aeruginosa in a clinically relevant mouse model of wound infection. The utility of 6″-18F-fluoromaltotriose to help monitor antibiotic therapies was also evaluated in rats. Conclusion
6″-18F-fluoromaltotriose is a promising new tracer that has significant diagnostic utility, with the potential to change the clinical management of patients with infectious diseases of bacterial origin.Society of Nuclear Medicine and Molecular Imaging