Effect of testosterone replacement therapy on prostate tissue in men with late-onset hypogonadism: a randomized controlled trial
LS Marks, NA Mazer, E Mostaghel, DL Hess, FJ Dorey… - Jama, 2006 - jamanetwork.com
ContextProstate safety is a primary concern when aging men receive testosterone
replacement therapy (TRT), but little information is available regarding the effects of TRT on
prostate tissue in men. ObjectiveTo determine the effects of TRT on prostate tissue of aging
men with low serum testosterone levels. Design, Setting, and ParticipantsRandomized,
double-blind, placebo-controlled trial of 44 men, aged 44 to 78 years, with screening serum
testosterone levels lower than 300 ng/dL (< 10.4 nmol/L) and related symptoms, conducted …
replacement therapy (TRT), but little information is available regarding the effects of TRT on
prostate tissue in men. ObjectiveTo determine the effects of TRT on prostate tissue of aging
men with low serum testosterone levels. Design, Setting, and ParticipantsRandomized,
double-blind, placebo-controlled trial of 44 men, aged 44 to 78 years, with screening serum
testosterone levels lower than 300 ng/dL (< 10.4 nmol/L) and related symptoms, conducted …