REM sleep behavioral disorder may be an independent risk factor for orthostatic hypotension in Parkinson's disease
K Yin, C Zhou, Y Zhu, W Yin, L Yin, B Liu, H Ren… - Aging Clinical and …, 2022 - Springer
K Yin, C Zhou, Y Zhu, W Yin, L Yin, B Liu, H Ren, Z Xu, X Yang
Aging Clinical and Experimental Research, 2022•SpringerPurpose The purpose of this study was to evaluate the association between clinically
possible rapid eye movement (REM) sleep behavioral disorder (pRBD) and orthostatic
hypotension (OH) in PD patients, as well as to explore the mechanisms underlying the
association. Methods PD patients (n= 116) were assigned to a group with OH (PD-OH) or
without OH (PD-NOH). General demographic and clinical data were collected. A series of
scales were used to assess the clinical symptoms in the two groups. Results A total of 27 …
possible rapid eye movement (REM) sleep behavioral disorder (pRBD) and orthostatic
hypotension (OH) in PD patients, as well as to explore the mechanisms underlying the
association. Methods PD patients (n= 116) were assigned to a group with OH (PD-OH) or
without OH (PD-NOH). General demographic and clinical data were collected. A series of
scales were used to assess the clinical symptoms in the two groups. Results A total of 27 …
Purpose
The purpose of this study was to evaluate the association between clinically possible rapid eye movement (REM) sleep behavioral disorder (pRBD) and orthostatic hypotension (OH) in PD patients, as well as to explore the mechanisms underlying the association.
Methods
PD patients (n = 116) were assigned to a group with OH (PD-OH) or without OH (PD-NOH). General demographic and clinical data were collected. A series of scales were used to assess the clinical symptoms in the two groups.
Results
A total of 27 patients (23.3%) had OH. The PD-OH group showed significantly higher H-Y staging score and significantly higher frequencies of pRBD, anxiety, depression, and cognitive impairment than the PD-NOH group. Binary logistic regression analysis identified the following factors as independently associated with PD-OH: H-Y staging [odds ratio (OR) 2.565, 95% confidence interval (CI) 1.160–5.673; P = 0.020], RBD (OR 7.680, 95% CI 1.944–30.346; P = 0.004), UPDRS II (OR 1.021, 95% CI 0.980–1.063; P = 0.020), depression (OR 7.601, 95% CI 1.492–38.718; P = 0.015), and cognitive impairment (OR 0.824, 95% CI 0.696–0.976; P = 0.025).
Conclusions
Our results suggest that pRBD is an independent risk factor for OH in patients with PD. We speculate that there may be a close relationship between RBD and OH, which requires attention. Early diagnosis of RBD may help predict the appearance of OH in PD patients.
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