[PDF][PDF] Systemic administration of STING agonist antibody-drug conjugates elicit potent anti-tumor immune responses with minimal induction of circulating cytokines
RA Bukhalid, JR Duvall, NM Cetinbas, KC Catcott… - Cancer Res, 2020 - mersana.com
RA Bukhalid, JR Duvall, NM Cetinbas, KC Catcott, K Avocetien, KW Bentley, S Bradley…
Cancer Res, 2020•mersana.comFigure 1. Depiction of the STING pathway (adapted from Corrales et al 1). cGAS recognizes
and binds to cytosolic dsDNA and synthesizes cGAMP, a natural STING agonist that
activates STING, which in return activates TBK1-mediated phosphorylation of IRF3
transcription factor, leading to expression of type I interferon and other interferon stimulated
genes and eventually to an anti-tumor immune response.
and binds to cytosolic dsDNA and synthesizes cGAMP, a natural STING agonist that
activates STING, which in return activates TBK1-mediated phosphorylation of IRF3
transcription factor, leading to expression of type I interferon and other interferon stimulated
genes and eventually to an anti-tumor immune response.
Figure 1. Depiction of the STING pathway (adapted from Corrales et al 1). cGAS recognizes and binds to cytosolic dsDNA and synthesizes cGAMP, a natural STING agonist that activates STING, which in return activates TBK1-mediated phosphorylation of IRF3 transcription factor, leading to expression of type I interferon and other interferon stimulated genes and eventually to an anti-tumor immune response.
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