Interleukin 5 in the link between the innate and acquired immune response
Abstract Interleukin‐5 (IL‐5) is an interdigitating homodimeric glycoprotein that is initially
identified by its ability to support the in vitro growth and differentiation of mouse B cells and
eosinophils. IL‐5 transgenic mouse shows two predominant features, remarkable increase
in B‐1 cells resulting in enhanced serum antibody levels, predominantly IgM, IgA, and IgE
classes and in expansion of eosinophil numbers in the blood and eosinophil infiltration into
various tissues. Conversely, mice lacking a functional gene for IL‐5 or IL‐5 receptor alpha …
identified by its ability to support the in vitro growth and differentiation of mouse B cells and
eosinophils. IL‐5 transgenic mouse shows two predominant features, remarkable increase
in B‐1 cells resulting in enhanced serum antibody levels, predominantly IgM, IgA, and IgE
classes and in expansion of eosinophil numbers in the blood and eosinophil infiltration into
various tissues. Conversely, mice lacking a functional gene for IL‐5 or IL‐5 receptor alpha …