Inhibition of polyamine biosynthesis using difluoromethylornithine acts as a potent immune modulator and displays therapeutic synergy with PD-1-blockade
P Dryja, C Fisher, PM Woster… - Journal of …, 2021 - journals.lww.com
Polyamines are known to play a significant role in cancer progression and treatment using
difluoromethylornithine (DFMO), an inhibitor of polyamine biosynthesis, has shown some
clinical promise. It is interesting to note that, while DFMO is directly cytostatic in vitro, recent
work has suggested that it achieves its antitumor efficacy in vivo by enhancing adaptive
antitumor immune responses. On the basis of these data, we hypothesized that DFMO might
act as an immune sensitizer to increase tumor responsiveness to checkpoint blockade. To …
difluoromethylornithine (DFMO), an inhibitor of polyamine biosynthesis, has shown some
clinical promise. It is interesting to note that, while DFMO is directly cytostatic in vitro, recent
work has suggested that it achieves its antitumor efficacy in vivo by enhancing adaptive
antitumor immune responses. On the basis of these data, we hypothesized that DFMO might
act as an immune sensitizer to increase tumor responsiveness to checkpoint blockade. To …