Macrophage expression of interleukin-10 is a prognostic factor in nonsmall cell lung cancer
E Zeni, L Mazzetti, D Miotto, NL Cascio… - European …, 2007 - Eur Respiratory Soc
E Zeni, L Mazzetti, D Miotto, NL Cascio, P Maestrelli, P Querzoli, M Pedriali, E De Rosa…
European Respiratory Journal, 2007•Eur Respiratory SocInterleukin (IL)-10 is expressed in many solid tumours and plays an ambiguous role in
controlling cancer growth and metastasis. In order to determine whether IL-10 is involved in
tumour progression and prognosis in nonsmall cell lung cancer (NSCLC), IL-10 expression
in tumour cells and tumour-associated macrophages (TAMs) and its associations, if any, with
clinicopathological features were investigated. Paraffin-embedded sections of surgical
specimens obtained from 50 patients who had undergone surgery for NSCLC were …
controlling cancer growth and metastasis. In order to determine whether IL-10 is involved in
tumour progression and prognosis in nonsmall cell lung cancer (NSCLC), IL-10 expression
in tumour cells and tumour-associated macrophages (TAMs) and its associations, if any, with
clinicopathological features were investigated. Paraffin-embedded sections of surgical
specimens obtained from 50 patients who had undergone surgery for NSCLC were …
Interleukin (IL)-10 is expressed in many solid tumours and plays an ambiguous role in controlling cancer growth and metastasis. In order to determine whether IL-10 is involved in tumour progression and prognosis in nonsmall cell lung cancer (NSCLC), IL-10 expression in tumour cells and tumour-associated macrophages (TAMs) and its associations, if any, with clinicopathological features were investigated.
Paraffin-embedded sections of surgical specimens obtained from 50 patients who had undergone surgery for NSCLC were immunostained with an antibody directed against IL-10. TAMs and tumour cells positive for IL-10 were subsequently quantified.
IL-10-positive TAM percentage was higher in patients with stage II, III and IV NSCLC, and in those with lymph node metastases compared with patients with stage I NSCLC. High IL-10 expression by TAMs was a significant independent predictor of advanced tumour stage, and thus was associated with worse overall survival. Conversely, IL-10 expression by tumour cells did not differ between stages II, III and IV and stage I NSCLC.
In conclusion, interleukin-10 expression by tumour-associated macrophages, but not by tumour cells, may play a role in the progression and prognosis of nonsmall cell lung cancer. These results may be useful in the development of novel approaches for anticancer treatments.
European Respiratory Society