ABSTRACT Background & Aim. Despite treatment with glucocorticoids, mortality remains
high in patients with severe alcoholic hepatitis. Oxidative stress and depletion of
mitochondrial glutathione are implicated factors in liver injury. The aim of this study was to
evaluate the impact of the addition of metadoxine, a drug which possesses a multifactorial
mechanism of action, including antioxidant properties, to standard treatment with
glucocorticoids in patients with severe alcoholic hepatitis. Material and methods. This …