Lack of efficacy of topical timolol for cutaneous telangiectasias in patients with hereditary hemorrhagic telangiectasia: results of a pilot study
H Jeon, B Cohen - Journal of the American Academy of Dermatology, 2017 - jaad.org
In this study, we explored the role of topical timolol for cutaneous telangiectasias in patients
with HHT. Timolol is a potent nonselective betaadrenergic blocking agent possessing 5-to
10-fold greater activity than propranolol, which has been successful in safely treating
infantile hemangioma. 2 Timolol can be used topically and has been used by
otolaryngologists to treat epistaxis in patients with HHT based on a limited number of cases
reported in the literature. 3, 4 Proposed mechanisms include vasoconstriction, endothelial …
with HHT. Timolol is a potent nonselective betaadrenergic blocking agent possessing 5-to
10-fold greater activity than propranolol, which has been successful in safely treating
infantile hemangioma. 2 Timolol can be used topically and has been used by
otolaryngologists to treat epistaxis in patients with HHT based on a limited number of cases
reported in the literature. 3, 4 Proposed mechanisms include vasoconstriction, endothelial …