Efficacy of timolol in a novel intranasal thermosensitive gel for hereditary hemorrhagic telangiectasia–associated epistaxis: a randomized clinical trial
AM Peterson, JJ Lee, D Kallogjeri… - … –Head & Neck …, 2020 - jamanetwork.com
Importance Other than nasal moisturizers, no standard-of-care medical therapy exists for
epistaxis in hereditary hemorrhagic telangiectasia (HHT). With epistaxis as the greatest
cause of morbidity in patients with HHT, there is a need to identify effective topical therapies.
Objective To determine the efficacy and safety of an intranasal timolol thermosensitive gel vs
placebo thermosensitive gel in treating HHT-associated epistaxis. Design, Setting, and
Participants This double-blind, placebo-controlled randomized clinical trial was conducted …
epistaxis in hereditary hemorrhagic telangiectasia (HHT). With epistaxis as the greatest
cause of morbidity in patients with HHT, there is a need to identify effective topical therapies.
Objective To determine the efficacy and safety of an intranasal timolol thermosensitive gel vs
placebo thermosensitive gel in treating HHT-associated epistaxis. Design, Setting, and
Participants This double-blind, placebo-controlled randomized clinical trial was conducted …