Revisiting tissue specificity of germline cancer predisposing mutations
JM Maris, AG Knudson - Nature Reviews Cancer, 2015 - nature.com
JM Maris, AG Knudson
Nature Reviews Cancer, 2015•nature.comHeritable germline mutations in major cancer genes generally lead to a restricted pattern of
tissue-specific malignancies, yet many of the same mutations frequently occur somatically in
a broad range of spontaneous neoplasms affecting different organs. Might this reflect a
difference in tumorigenesis in children and adults?
tissue-specific malignancies, yet many of the same mutations frequently occur somatically in
a broad range of spontaneous neoplasms affecting different organs. Might this reflect a
difference in tumorigenesis in children and adults?
Abstract
Heritable germline mutations in major cancer genes generally lead to a restricted pattern of tissue-specific malignancies, yet many of the same mutations frequently occur somatically in a broad range of spontaneous neoplasms affecting different organs. Might this reflect a difference in tumorigenesis in children and adults?
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