[HTML][HTML] Establishment of True Niacin Deficiency in Quinolinic Acid Phosphoribosyltransferase Knockout Mice, 3
M Terakata, T Fukuwatari, M Sano, N Nakao… - The Journal of …, 2012 - Elsevier
Pyridine nucleotide coenzymes are involved in> 500 enzyme reactions and are
biosynthesized from the amino acid L-tryptophan (L-Trp) as well as the vitamin niacin.
Hence,“true” niacin-deficient animals cannot be “created” using nutritional techniques. We
wanted to establish a truly niacin-deficient model animal using a protocol that did not involve
manipulating dietary L-Trp. We generated mice that are missing the quinolinic acid (QA)
phosphoribosyltransferase (QPRT) gene. QPRT activity was not detected inqprt–/–mice …
biosynthesized from the amino acid L-tryptophan (L-Trp) as well as the vitamin niacin.
Hence,“true” niacin-deficient animals cannot be “created” using nutritional techniques. We
wanted to establish a truly niacin-deficient model animal using a protocol that did not involve
manipulating dietary L-Trp. We generated mice that are missing the quinolinic acid (QA)
phosphoribosyltransferase (QPRT) gene. QPRT activity was not detected inqprt–/–mice …