Intrinsic control of sodium excretion in the distal nephron by inhibitory purinergic regulation of the epithelial Na+ channel
GM Toney, V Vallon, JD Stockand - Current opinion in nephrology …, 2012 - journals.lww.com
GM Toney, V Vallon, JD Stockand
Current opinion in nephrology and hypertension, 2012•journals.lww.comPurinergic inhibitory regulation of ENaC is a key component of an intrinsic control system
that enables the distal nephron to respond appropriately to the delivered load of sodium.
This control system is physiologically important and functions in parallel with extrinsic control
by the renin–angiotensin–aldosterone system, enabling sodium excretion to keep pace with
sodium intake, especially when intake is high, and thereby maintaining arterial blood
pressure. Disruption of intrinsic control of sodium transport by the distal nephron likely …
that enables the distal nephron to respond appropriately to the delivered load of sodium.
This control system is physiologically important and functions in parallel with extrinsic control
by the renin–angiotensin–aldosterone system, enabling sodium excretion to keep pace with
sodium intake, especially when intake is high, and thereby maintaining arterial blood
pressure. Disruption of intrinsic control of sodium transport by the distal nephron likely …
Summary
Purinergic inhibitory regulation of ENaC is a key component of an intrinsic control system that enables the distal nephron to respond appropriately to the delivered load of sodium. This control system is physiologically important and functions in parallel with extrinsic control by the renin–angiotensin–aldosterone system, enabling sodium excretion to keep pace with sodium intake, especially when intake is high, and thereby maintaining arterial blood pressure. Disruption of intrinsic control of sodium transport by the distal nephron likely contributes to diseases such as arterial hypertension.
Lippincott Williams & Wilkins