A retroviral peptide encoded by mutated env p15E gene is recognized by specific CD8+ T lymphocytes on drug-treated murine mastocytoma P815
ML Belladonna, MC Fioretti, R Bianchi… - International journal of …, 1996 - Elsevier
Highly immunogenic (“xenogenized”) tumour variants appear after treatment of murine
mastocytoma P815 with the triazene derivative DTIC, a phenomenon associated with the
appearance of structurally abnormal p15E env proteins in the variant cells. In the present
study, we have isolated and sequenced several p15E cDNA gene fragments amplified by
means of polymerase chain reaction (PCR) from parental (P815) and xenogenized
(P815/DTIC) tumour cells. Compared to known p15E sequences in parental cells, one p15E …
mastocytoma P815 with the triazene derivative DTIC, a phenomenon associated with the
appearance of structurally abnormal p15E env proteins in the variant cells. In the present
study, we have isolated and sequenced several p15E cDNA gene fragments amplified by
means of polymerase chain reaction (PCR) from parental (P815) and xenogenized
(P815/DTIC) tumour cells. Compared to known p15E sequences in parental cells, one p15E …